Current: Catalog Peptides : Orexins

 
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Cat# 46-2-70A
Sequence Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2
Unit
Weight 0.5  mg
MW 3561.2
CAS
Formula C152H243N47044S4
Disulfide Bridge Disulfide bridges Cys6-Cys12, Cys7-Cys14
References            M.W. Schwartz, Nature Med., 4, 385 (1998); T. Sakurai et al., Cell, 92, 573 (1998)

Orexin A, human 

 

Orexin A is a hypothalamic neuropeptide that regulates feeding behavior. This peptide significantly augment food intake in a dose-dependent manner when a bolus was administered intracerebroventricularly. After a 48 hours fast, hypothalamic prpro-orexin mRNA level is up-regulated 2.4. The discovery of Orexins and their receptors may provide a novel molecular basis for understanding the role of the lateral hypothalamic areas in the regulation of energy homeostasis.