Current: Catalog Peptides : Orexins

 
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Cat# 46-2-71B
Sequence Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
Unit
Weight 1.0  mg
MW 2898.4
CAS
Formula C123H211N44O35S1
Disulfide Bridge
References            M.W. Schwartz, <I>Nature Med<$>., 4, 385 (1998); T. Sakurai et al., Cell, 92, 573 (1998)

Orexin B, human 

 

Orexin B is a hypothalamic neuropeptide that regulates feeding behavior. This peptide significantly augments food intake in a dose-dependent manner when a bolus was administered intracerebroventricularly. After a 48 hour fast, hypothalamic prepro-orexin mRNA level is up-regulated 2.4. The discovery of Orexins and their receptors may provide a novel molecular basis for understanding the role of the lateral hypothalamic areas in the regulation of energy homeostasis.