: Myelin Oligodendrocyte Glycoprotein (MOG) Peptide
References Lit. M. Ichikawa et al., J. Immunol. 157, 919 (1996)/ J. liu et al., Nature Med. 4, 78 (1998)
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), rat, mouse
MOG peptide (35-55) is highly encephalitogenic and can induce strong T and B cell responses. A single injection of this peptide produces a relapsing- remitting neurologic disease with extensive plaque-like demyelination. Because of the clinical, histophathologic, and immunologic similarities with multiple sclerosis (MS), the MOG induced demyelinating encephalomyelitis may serve as a model for investigating MS.
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