# DSIP

> Endogenous nonapeptide first isolated for its sleep-promoting properties.

- Also known as: Delta Sleep-Inducing Peptide
- Class: Cognitive
- FDA approved: No
- Canonical page: https://www.americanpeptide.com/catalog/dsip

## Overview

DSIP is a nine-amino-acid neuropeptide first isolated from rabbit cerebral venous blood. Reported effects span sleep architecture, stress response, and circadian rhythm modulation.

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nine-amino-acid neuropeptide, first isolated in the 1970s from the blood of rabbits during induced sleep. Its name reflects the early observation that it promoted slow-wave (delta) sleep.

Decades of research have linked DSIP to sleep architecture, stress-response regulation, and circadian rhythm, but its precise mechanism and receptor remain incompletely characterized. It is a research compound and is not FDA-approved.

## Mechanism

Mechanism remains incompletely characterized; likely multimodal CNS modulation.

## Chemistry

| Property | Value |
| --- | --- |
| Molecular formula | C35H48N10O15 |
| Molecular weight | 848.8 Da |
| CAS number | 62568-57-4 |
| PubChem CID | [68816](https://pubchem.ncbi.nlm.nih.gov/compound/68816) |

## Sequence

```
WAGGDASGE
```

## Research areas

Studied in: Sleep biology, Stress physiology.

Guides on this site:

- [Anxiety, Mood & Stress](https://www.americanpeptide.com/research-areas/anxiety-mood): Regulatory peptides studied for anxiolysis and stress-axis modulation.
- [Sleep & Circadian Rhythm](https://www.americanpeptide.com/research-areas/sleep-circadian): Peptides studied for sleep architecture and circadian regulation.

## Key research

- Sleep architecture — studied for effects on slow-wave (delta) sleep.
- Stress physiology — examined for interactions with the stress axis.
- Circadian rhythm — investigated as a modulator of biological timing.
- Uncharacterized mechanism — receptor and pathway not fully established.
- Not FDA-approved — research compound.

## FAQs

### What is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide first isolated for its sleep-promoting properties, studied in sleep and stress research.

### How does DSIP work?

Its mechanism is not fully characterized; it is thought to act through multiple central nervous system pathways rather than a single identified receptor.

### What is it studied for?

Sleep architecture, stress physiology, and circadian rhythm modulation.

### Is it approved?

No — it is a research compound. This page is a research and educational reference.

## Latest research

Recent trials and publications mentioning Delta Sleep-Inducing Peptide, pulled automatically from ClinicalTrials.gov and PubMed (unfiltered search results, refreshed daily).

### Recent trials

- [Study of the Efficacy, Safety, Pharmacokinetics, and Immunogenicity of Netakimab in Children With Moderate to Severe Plaque Psoriasis](https://clinicaltrials.gov/study/NCT06640517) — ACTIVE_NOT_RECRUITING · PHASE3 · NCT06640517
- [Harm Reduction Intervention for Anabolic-androgenic Steroids Users: a Randomized Controlled Trial](https://clinicaltrials.gov/study/NCT07039539) — NOT_YET_RECRUITING · NA · NCT07039539
- [Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder](https://clinicaltrials.gov/study/NCT07523633) — RECRUITING · PHASE2 · NCT07523633
- [Young Adults With Early-onset Obesity Treated With Semaglutide](https://clinicaltrials.gov/study/NCT05574439) — COMPLETED · PHASE4 · NCT05574439
- [Effectiveness of Immersive Virtual Reality on Biomarkers and Clinical and Clinimetric Variables in Patients With Persistent Shoulder Pain](https://clinicaltrials.gov/study/NCT06795464) — COMPLETED · NA · NCT06795464
- [Effects on Remission of Type 2 Diabetes Mellitus Following Gastric Bypass Alone vs Gastric Bypass Combined With Truncal Vagotomy](https://clinicaltrials.gov/study/NCT07278115) — RECRUITING · NA · NCT07278115

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Source: AmericanPeptide.com — https://www.americanpeptide.com/catalog/dsip
Data license: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Attribution: AmericanPeptide.com.
Research reference only — computational and educational content, not medical advice.