# Kisspeptin-10

> C-terminal decapeptide fragment of kisspeptin; potent GnRH secretagogue.

- Class: Reproductive
- FDA approved: No
- Canonical page: https://www.americanpeptide.com/catalog/kisspeptin-10

## Overview

Kisspeptin-10 (KP-10) is the minimum bioactive fragment of kisspeptin, encoded by KISS1. Administration stimulates hypothalamic GnRH release and downstream LH / FSH secretion.

Kisspeptin-10 is the shortest fully active fragment of kisspeptin, the neuropeptide encoded by the KISS1 gene that sits at the top of the reproductive hormone cascade. It signals through the KISS1R (GPR54) receptor on hypothalamic GnRH neurons.

By stimulating GnRH release, kisspeptin drives downstream secretion of LH and FSH — making it a research tool for probing and potentially restoring reproductive-axis function. It is investigational and not FDA-approved.

## Mechanism

KISS1R (GPR54) agonism on hypothalamic GnRH neurons.

## Chemistry

| Property | Value |
| --- | --- |
| Molecular formula | C63H83N17O14 |
| Molecular weight | 1302.4 Da |
| PubChem CID | [25240297](https://pubchem.ncbi.nlm.nih.gov/compound/25240297) |

## Sequence

```
YNWNSFGLRF-NH2
```

## Research areas

Studied in: Reproductive endocrinology, Hypothalamic amenorrhea, Puberty.

Guides on this site:

- [Sexual & Reproductive Health](https://www.americanpeptide.com/research-areas/sexual-reproductive): Peptides studied across the HPG axis and CNS sexual-response pathways.

## Key research

- GnRH stimulation — KISS1R (GPR54) agonism on hypothalamic GnRH neurons increases GnRH pulsatility and downstream LH / FSH and sex-steroid secretion.
- Reproductive-axis probe — studied for restoring signaling in hypothalamic amenorrhea and as a physiologic trigger of LH / FSH in fertility research.
- Puberty & limbic effects — a key regulator of pubertal onset; KISS1R is also expressed in limbic areas, enabling direct central sexual-motivation effects.
- Compared to PT-141 — kisspeptin acts upstream on the hormonal axis (GnRH → LH / FSH), where PT-141 produces acute central arousal via melanocortin receptors.
- Investigational — not FDA-approved.

## FAQs

### What is Kisspeptin-10?

Kisspeptin-10 is the active fragment of kisspeptin, a neuropeptide that triggers GnRH release at the top of the reproductive hormone axis.

### What is the HPG-axis connection?

Kisspeptin is the upstream regulator of the hypothalamic-pituitary-gonadal axis, stimulating GnRH and downstream LH and FSH.

### What is it studied for?

Reproductive endocrinology, hypothalamic amenorrhea, puberty, and fertility research.

### Is it approved?

No — it is investigational. This page is a research and educational reference.

## Latest research

Recent trials and publications mentioning Kisspeptin-10, pulled automatically from ClinicalTrials.gov and PubMed (unfiltered search results, refreshed daily).

### Recent trials

- [Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp](https://clinicaltrials.gov/study/NCT05456854) — WITHDRAWN · PHASE1 · NCT05456854
- [Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance](https://clinicaltrials.gov/study/NCT04532801) — WITHDRAWN · PHASE1 · NCT04532801
- [KP-10 and Insulin Secretion in Men](https://clinicaltrials.gov/study/NCT03771326) — COMPLETED · PHASE3 · NCT03771326
- [Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men](https://clinicaltrials.gov/study/NCT03315325) — COMPLETED · PHASE3 · NCT03315325
- [Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.](https://clinicaltrials.gov/study/NCT03286517) — COMPLETED · PHASE3 · NCT03286517

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Source: AmericanPeptide.com — https://www.americanpeptide.com/catalog/kisspeptin-10
Data license: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Attribution: AmericanPeptide.com.
Research reference only — computational and educational content, not medical advice.