# KPV

> Anti-inflammatory C-terminal tripeptide of α-MSH.

- Class: Immune, Healing & Repair
- FDA approved: No
- Canonical page: https://www.americanpeptide.com/catalog/kpv

## Overview

KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-MSH and retains much of α-MSH's anti-inflammatory activity without pigmentary effects. Preclinical work in colitis and skin inflammation models.

KPV is the C-terminal tripeptide (lysine-proline-valine) of α-melanocyte-stimulating hormone (α-MSH). It retains much of the parent hormone’s anti-inflammatory activity while shedding its pigmentary effects, making it a focused research tool for inflammation.

Preclinical studies report that KPV reduces pro-inflammatory signaling — in part by interfering with the NF-κB pathway — in models of colitis, skin inflammation, and oral inflammation. It is a research compound and is not FDA-approved.

## Mechanism

NF-κB pathway inhibition; reduction of pro-inflammatory cytokines.

## Chemistry

| Property | Value |
| --- | --- |
| Molecular formula | C16H30N4O4 |
| Molecular weight | 342.4 Da |
| PubChem CID | [125672](https://pubchem.ncbi.nlm.nih.gov/compound/125672) |

## Sequence

```
KPV
```

## Research areas

Studied in: IBD models, Atopic dermatitis, Oral inflammation.

Guides on this site:

- [Immune & Inflammation](https://www.americanpeptide.com/research-areas/immune-inflammation): Thymic and host-defense peptides studied for immune modulation.

## Key research

- Anti-inflammatory signaling — NF-κB pathway inhibition reducing cytokine output.
- Inflammatory bowel disease — studied in colitis models.
- Skin inflammation — examined in atopic-dermatitis models.
- No pigmentary effect — retains α-MSH anti-inflammation without tanning.
- Preclinical — not FDA-approved.

## FAQs

### What is KPV?

KPV is the anti-inflammatory C-terminal tripeptide of α-MSH, studied in preclinical models of colitis and skin inflammation.

### How is it related to α-MSH?

KPV is the final three residues of α-MSH and keeps much of its anti-inflammatory activity without the pigmentation effect.

### What is it studied for?

Inflammatory bowel disease, atopic dermatitis, and oral inflammation, primarily in preclinical models.

### Is it approved?

No — it is a research compound. This page is a research and educational reference.

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Source: AmericanPeptide.com — https://www.americanpeptide.com/catalog/kpv
Data license: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Attribution: AmericanPeptide.com.
Research reference only — computational and educational content, not medical advice.