# NAD+

> Essential redox cofactor central to mitochondrial bioenergetics and sirtuin activity.

- Also known as: Nicotinamide Adenine Dinucleotide
- Class: Mitochondrial, Longevity
- FDA approved: No
- Canonical page: https://www.americanpeptide.com/catalog/nad-plus

## Overview

NAD+ is a ubiquitous coenzyme required for electron transport, sirtuin activity, and PARP-mediated DNA repair. Often supplied as a research reagent and increasingly as an investigational therapeutic.

NAD+ (nicotinamide adenine dinucleotide) is not a peptide but a universal coenzyme, included here for its central place in metabolic and longevity research. Every cell uses it to carry electrons through energy metabolism and to power signaling enzymes.

Two enzyme families make NAD+ a focus of aging research: sirtuins, which depend on it to regulate gene expression and stress resistance, and PARPs, which use it for DNA repair. Cellular NAD+ declines with age, and restoring it — directly or via precursors — is widely studied.

## Mechanism

Cofactor for hundreds of redox and signaling enzymes including sirtuins and PARPs.

## Chemistry

| Property | Value |
| --- | --- |
| Molecular formula | C21H27N7O14P2 |
| Molecular weight | 663.4 Da |
| CAS number | 53-84-9 |
| PubChem CID | [5893](https://pubchem.ncbi.nlm.nih.gov/compound/5893) |

## Research areas

Studied in: Aging biology, Mitochondrial dysfunction, Neurodegeneration.

Guides on this site:

- [Cognition & Neuroprotection](https://www.americanpeptide.com/research-areas/cognition-neuroprotection): Nootropic and neurotrophic peptides studied for cognition and recovery.
- [Longevity & Aging](https://www.americanpeptide.com/research-areas/longevity-aging): Peptides studied across the aging axis — senescence, NAD+, and resilience.
- [Mitochondrial & Bioenergetics](https://www.americanpeptide.com/research-areas/mitochondrial): Mitochondria-targeted peptides studied for bioenergetics and cardiolipin.

## Key research

- Energy metabolism — essential electron carrier in the mitochondrial electron-transport chain.
- Sirtuin activity — required cofactor for sirtuin-mediated longevity signaling.
- DNA repair — consumed by PARP enzymes during repair.
- Age-related decline — NAD+ falls with age, a central theme in longevity research.
- Cofactor / reagent — supplied as a research reagent and investigational therapeutic.

## FAQs

### What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme central to energy metabolism, sirtuin activity, and DNA repair — a major focus of aging research.

### Is NAD+ a peptide?

No — it is a coenzyme (a dinucleotide), included in the catalog for its central role in mitochondrial and longevity research.

### Why does NAD+ matter for aging?

Cellular NAD+ declines with age, and the sirtuin and PARP enzymes that depend on it govern stress resistance and DNA repair, so restoring NAD+ is widely studied.

### Is it approved?

NAD+ is used as a research reagent and studied as an investigational therapeutic. This page is a research and educational reference.

## Latest research

Recent trials and publications mentioning Nicotinamide Adenine Dinucleotide, pulled automatically from ClinicalTrials.gov and PubMed (unfiltered search results, refreshed daily).

### Recent trials

- [Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial](https://clinicaltrials.gov/study/NCT03868293) — RECRUITING · NA · NCT03868293
- [Notched Noise Therapy for Suppression of Tinnitus](https://clinicaltrials.gov/study/NCT04661995) — COMPLETED · NA · NCT04661995
- [Fluorescence Guided Focal Cortical Dysplasia Surgery](https://clinicaltrials.gov/study/NCT07657975) — NOT_YET_RECRUITING · PHASE2 · NCT07657975
- [Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis](https://clinicaltrials.gov/study/NCT07655791) — NOT_YET_RECRUITING · PHASE4 · NCT07655791
- [Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism](https://clinicaltrials.gov/study/NCT07649161) — RECRUITING · NA · NCT07649161
- [Effect of NUV001 Supplementation in Patients Suffering From Sickle Cell Disease (SCD)](https://clinicaltrials.gov/study/NCT05789355) — COMPLETED · NA · NCT05789355

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Source: AmericanPeptide.com — https://www.americanpeptide.com/catalog/nad-plus
Data license: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Attribution: AmericanPeptide.com.
Research reference only — computational and educational content, not medical advice.