# Pancragen

> Synthetic Lys-Glu-Asp-Trp tetrapeptide studied as a pancreas-tissue bioregulator.

- Also known as: Lys-Glu-Asp-Trp, KEDW tetrapeptide, Pancragen
- Class: Bioregulators, Metabolic
- FDA approved: No
- Canonical page: https://www.americanpeptide.com/catalog/pancragen

## Overview

Pancragen is a synthetic tetrapeptide (Lys-Glu-Asp-Trp) in the Khavinson short-peptide bioregulator series, studied for effects on pancreatic tissue and carbohydrate metabolism.

Pancragen (Lys-Glu-Asp-Trp) is the pancreas-directed member of the defined short-peptide bioregulator family, studied in the context of age-related metabolic and pancreatic decline in the originating research tradition.

Reported research examined markers of pancreatic function and carbohydrate metabolism in models, consistent with the class hypothesis of tissue-selective transcriptional modulation. Evidence is concentrated in one research tradition with limited independent replication, and it is not FDA-approved.

## Mechanism

Proposed gene-regulatory modulation of pancreatic gene expression.

## Chemistry

| Property | Value |
| --- | --- |
| Molecular weight | 576.6 Da |

## Sequence

```
KEDW
```

## Research areas

Studied in: Metabolic, Aging biology, Peptide bioregulators.

Guides on this site:

- [Weight Loss & Metabolic Health](https://www.americanpeptide.com/research-areas/weight-loss): Incretin and metabolic peptides studied for glycemic control and fat loss.
- [Longevity & Aging](https://www.americanpeptide.com/research-areas/longevity-aging): Peptides studied across the aging axis — senescence, NAD+, and resilience.
- [Peptide Bioregulators](https://www.americanpeptide.com/research-areas/bioregulators): Short, tissue-specific peptides proposed to regulate gene expression — the Khavinson series.

## Key research

- Pancreatic / metabolic focus — studied for effects on pancreatic tissue markers and carbohydrate-metabolism endpoints in preclinical models.
- Class mechanism — proposed short peptide–DNA interaction driving tissue-selective gene expression.
- Evidence quality — single-tradition and largely preclinical; preliminary.

## FAQs

### What is Pancragen?

Pancragen is a synthetic Lys-Glu-Asp-Trp tetrapeptide studied as a pancreas-tissue bioregulator in the Khavinson short-peptide series.

### What tissue is it associated with?

The pancreas — each bioregulator in the series is framed around a specific target tissue.

### How strong is the evidence?

It is concentrated in a single research tradition and is largely preclinical, so findings are preliminary. This page is a research and educational reference.

---

Source: AmericanPeptide.com — https://www.americanpeptide.com/catalog/pancragen
Data license: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Attribution: AmericanPeptide.com.
Research reference only — computational and educational content, not medical advice.