# Pinealon

> Synthetic Glu-Asp-Arg tripeptide studied as a brain/CNS bioregulator.

- Also known as: Glu-Asp-Arg, EDR tripeptide
- Class: Cognitive, Bioregulators
- FDA approved: No
- Canonical page: https://www.americanpeptide.com/catalog/pinealon

## Overview

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) in the Khavinson short-peptide bioregulator series, studied for neuroprotective and CNS-directed effects.

Pinealon (Glu-Asp-Arg) is the brain-directed member of the defined short-peptide bioregulator family. It is studied in the same gene-regulatory framework as Epitalon, but framed around neuronal tissue rather than the pineal/aging axis.

Reported research examined protection of neurons against hypoxic and oxidative stress and effects on cognition in animal models. As with the rest of the class, the data originate largely from one research tradition, independent replication is limited, and it is not FDA-approved.

## Mechanism

Proposed gene-regulatory modulation of neuronal gene expression; reported antioxidant / anti-apoptotic effects in neural models.

## Chemistry

| Property | Value |
| --- | --- |
| Molecular weight | 418.4 Da |

## Sequence

```
EDR
```

## Research areas

Studied in: Cognition, Neuroprotection, Aging biology, Peptide bioregulators.

Guides on this site:

- [Cognition & Neuroprotection](https://www.americanpeptide.com/research-areas/cognition-neuroprotection): Nootropic and neurotrophic peptides studied for cognition and recovery.
- [Longevity & Aging](https://www.americanpeptide.com/research-areas/longevity-aging): Peptides studied across the aging axis — senescence, NAD+, and resilience.
- [Peptide Bioregulators](https://www.americanpeptide.com/research-areas/bioregulators): Short, tissue-specific peptides proposed to regulate gene expression — the Khavinson series.

## Key research

- Neuroprotection — studied for reduced neuronal apoptosis and oxidative damage under hypoxic/oxidative stress in cell and animal models.
- Cognition — examined for effects on learning and behavioral endpoints in rodent models.
- Class mechanism — proposed short peptide–DNA interaction modulating neuronal gene expression, shared with the wider bioregulator series.
- Evidence quality — single-tradition and largely preclinical; preliminary.

## FAQs

### What is Pinealon?

Pinealon is a synthetic Glu-Asp-Arg tripeptide studied as a brain/CNS bioregulator in the Khavinson short-peptide series.

### What is it studied for?

Neuroprotection under oxidative or hypoxic stress and cognition endpoints, mostly in preclinical models.

### How strong is the evidence?

It is concentrated in a single research tradition and is largely preclinical, so findings are preliminary. This page is a research and educational reference.

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Source: AmericanPeptide.com — https://www.americanpeptide.com/catalog/pinealon
Data license: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Attribution: AmericanPeptide.com.
Research reference only — computational and educational content, not medical advice.