# Sermorelin

> Truncated GHRH(1-29) — historically the first GHRH analog approved by the FDA.

- Also known as: GRF 1-29, Geref
- Class: Growth Hormone
- FDA approved: No
- Canonical page: https://www.americanpeptide.com/catalog/sermorelin

## Overview

Sermorelin is the first 29 amino acids of endogenous GHRH and was approved by the FDA in 1990 (subsequently discontinued commercially) for diagnostic and pediatric GH deficiency use.

Sermorelin is the first 29 amino acids of endogenous GHRH — the shortest fragment that retains full GH-releasing activity. As a GHRH-receptor agonist it prompts the pituitary to release the body’s own growth hormone.

It was FDA-approved in 1990 (Geref) for diagnostic evaluation of pituitary GH reserve and for pediatric GH deficiency, but was later discontinued commercially. It remains a widely referenced GHRH analog in research.

## Mechanism

GHRH receptor agonism.

## Chemistry

| Property | Value |
| --- | --- |
| Molecular formula | C149H246N44O42S |
| Molecular weight | 3358 Da |
| CAS number | 86168-78-7 |
| PubChem CID | [16132413](https://pubchem.ncbi.nlm.nih.gov/compound/16132413) |

## Sequence

```
YADAIFTNSYRKVLGQLSARKLLQDIMSR
```

## Research areas

Studied in: GH axis evaluation, Pediatric GH deficiency (historical).

Guides on this site:

- [Growth Hormone & Body Composition](https://www.americanpeptide.com/research-areas/growth-hormone-axis): Secretagogues studied for GH release, IGF-1, and body composition.

## Key research

- GHRH-receptor agonism — binds GHRHR on pituitary somatotrophs, activating adenylyl cyclase / cAMP to drive endogenous GH synthesis and release.
- Physiologic pulsatility — the short half-life is a design feature, producing a discrete GH pulse that preserves somatostatin negative feedback rather than sustained elevation.
- GH-axis evaluation — historically used to test pituitary GH reserve; a former approved use in pediatric GH deficiency, since discontinued.
- Compared to CJC-1295 — the same GHRH(1-29) backbone; CJC-1295 stabilizes and (with DAC) extends it for multi-day action, trading pulsatility for duration.
- Discontinued commercially — referenced today as a research compound.

## FAQs

### What is sermorelin?

Sermorelin is GHRH(1-29), the shortest active fragment of growth-hormone-releasing hormone, historically approved to assess and treat GH deficiency.

### Is sermorelin still FDA-approved?

It was approved in 1990 (Geref) but later discontinued commercially. It is referenced today largely as a research compound.

### How does it differ from CJC-1295?

CJC-1295 is a stabilized, longer-acting modification of the same GHRH(1-29) backbone; sermorelin is the unmodified fragment with a short half-life.

### Is this medical advice?

No — this page is a research and educational reference.

## Latest research

Recent trials and publications mentioning Sermorelin, pulled automatically from ClinicalTrials.gov and PubMed (unfiltered search results, refreshed daily).

### Recent trials

- [Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation](https://clinicaltrials.gov/study/NCT06701071) — RECRUITING · PHASE4 · NCT06701071
- [Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV](https://clinicaltrials.gov/study/NCT06554717) — RECRUITING · PHASE2 · NCT06554717
- [Body Composition and Adipose Tissue in HIV](https://clinicaltrials.gov/study/NCT03226821) — TERMINATED · PHASE4 · NCT03226821
- [Tesamorelin for Reduction of Liver Fat in Adults With Fatty Liver Disease (Mock Study)](https://clinicaltrials.gov/study/NCT07481734) — RECRUITING · PHASE2 · NCT07481734
- [Growth Hormone Releasing Hormone Analog to Improve Nonalcoholic Fatty Liver Disease and Associated Cardiovascular Risk](https://clinicaltrials.gov/study/NCT03375788) — COMPLETED · PHASE2 · NCT03375788
- [Adult Growth Hormone Deficiency and Cardiovascular Risk](https://clinicaltrials.gov/study/NCT00720902) — TERMINATED · PHASE4 · NCT00720902

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Source: AmericanPeptide.com — https://www.americanpeptide.com/catalog/sermorelin
Data license: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Attribution: AmericanPeptide.com.
Research reference only — computational and educational content, not medical advice.