# TB-500

> Synthetic fragment of thymosin β4 studied for cell migration and tissue repair.

- Also known as: Thymosin Beta-4 fragment
- Class: Healing & Repair
- FDA approved: No
- Canonical page: https://www.americanpeptide.com/catalog/tb-500

## Overview

TB-500 corresponds to the active actin-binding region of thymosin β4. Preclinical studies report effects on endothelial cell migration, angiogenesis, and wound healing.

TB-500 is a synthetic peptide corresponding to the actin-binding region of thymosin β4, a naturally occurring protein involved in cell migration and tissue repair. By sequestering G-actin, thymosin β4 influences cytoskeletal dynamics, and TB-500 is studied as a fragment that reproduces part of this activity.

As with BPC-157, the evidence for TB-500 is largely preclinical and it is not FDA-approved; it is also a prohibited substance in regulated sport. Research interest centers on endothelial cell migration, angiogenesis, and wound healing, with cardiac and dermal repair among the contexts studied.

## Mechanism

G-actin sequestration; modulation of cell migration and angiogenesis.

## Chemistry

| Property | Value |
| --- | --- |
| Molecular formula | C38H68N10O14 |
| Molecular weight | 889 Da |
| PubChem CID | [62707662](https://pubchem.ncbi.nlm.nih.gov/compound/62707662) |

## Sequence

```
LKKTETQ
```

## Research areas

Studied in: Wound healing, Cardiac repair models, Hair growth.

Guides on this site:

- [Wound Healing & Tissue Repair](https://www.americanpeptide.com/research-areas/wound-healing): Regenerative peptides studied for soft-tissue, tendon, and vascular repair.
- [Skin & Hair](https://www.americanpeptide.com/research-areas/skin-hair): Peptides studied for skin aging, pigmentation, and hair follicle biology.

## Key research

- Actin regulation — corresponds to the actin-binding motif of thymosin β4; promotes G-actin sequestration and the polymerization / depolymerization cycle that mobilizes cells to injury sites.
- Angiogenesis & re-epithelialization — thymosin β4 research reports accelerated wound closure in rodent full-thickness models, with increased collagen deposition and new-vessel growth.
- Cardiac & dermal repair — investigated in myocardial-injury and dermal wound models, and explored in hair-follicle biology.
- Compared to BPC-157 — complementary mechanism: TB-500 is migration-led (actin / cell mobilization) while BPC-157 is perfusion-led (angiogenesis / NO).
- Evidence quality — much of the data derives from thymosin β4 rather than the TB-500 fragment specifically; preclinical, not FDA-approved, and prohibited by WADA.

## Storage, handling & synthesis

**Storage.** Lyophilized: store frozen and protected from light for long-term stability. Reconstituted: refrigerate at 2–8 °C and use within weeks.

**Handling.** Reconstitute gently and avoid shaking; protect from heat, light, and repeated freeze–thaw.

## FAQs

### What is TB-500?

TB-500 is a synthetic peptide based on the actin-binding region of thymosin β4, studied in preclinical models for cell migration and tissue repair.

### How is TB-500 related to thymosin β4?

TB-500 corresponds to the active actin-binding fragment of the larger thymosin β4 protein, reproducing part of its cytoskeletal activity.

### Is TB-500 approved or allowed in sport?

No — it is not FDA-approved and is prohibited by the World Anti-Doping Agency. This page is a research and educational reference.

### What is TB-500 studied for?

Research contexts include wound healing, angiogenesis, cardiac repair, and hair-follicle biology, primarily in animal and cell models.

## Latest research

Recent trials and publications mentioning TB-500, pulled automatically from ClinicalTrials.gov and PubMed (unfiltered search results, refreshed daily).

### Recent trials

- [TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD](https://clinicaltrials.gov/study/NCT07487363) — RECRUITING · PHASE1, PHASE2 · NCT07487363

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Source: AmericanPeptide.com — https://www.americanpeptide.com/catalog/tb-500
Data license: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Attribution: AmericanPeptide.com.
Research reference only — computational and educational content, not medical advice.