# Vesugen

> Synthetic Lys-Glu-Asp tripeptide studied as a vascular-axis bioregulator.

- Also known as: Lys-Glu-Asp, KED tripeptide
- Class: Bioregulators, Longevity
- FDA approved: No
- Canonical page: https://www.americanpeptide.com/catalog/vesugen

## Overview

Vesugen is a synthetic tripeptide (Lys-Glu-Asp) in the Khavinson short-peptide bioregulator series, studied for tissue-specific effects on the vascular wall and endothelium.

Vesugen (Lys-Glu-Asp) is the vascular-targeted member of the defined short-peptide bioregulator family. Each peptide in the series is associated with a specific tissue; Vesugen is framed around the blood-vessel wall and endothelial function.

Reported research examined endothelial markers and vascular-tone regulation in cell and animal models, consistent with the class hypothesis of tissue-selective transcriptional modulation. Evidence is concentrated in the originating research tradition, independent replication is limited, and it is not FDA-approved.

## Mechanism

Proposed gene-regulatory modulation of vascular/endothelial gene expression.

## Chemistry

| Property | Value |
| --- | --- |
| Molecular weight | 390.4 Da |

## Sequence

```
KED
```

## Research areas

Studied in: Vascular biology, Aging biology, Peptide bioregulators.

Guides on this site:

- [Longevity & Aging](https://www.americanpeptide.com/research-areas/longevity-aging): Peptides studied across the aging axis — senescence, NAD+, and resilience.
- [Peptide Bioregulators](https://www.americanpeptide.com/research-areas/bioregulators): Short, tissue-specific peptides proposed to regulate gene expression — the Khavinson series.

## Key research

- Vascular focus — studied for effects on endothelial cell function and markers of vascular regulation in preclinical models.
- Class mechanism — proposed short peptide–DNA interaction driving tissue-selective gene expression, the shared hypothesis across the Vesugen/Pinealon/Cardiogen series.
- Evidence quality — single-tradition and largely preclinical; treat as preliminary.

## FAQs

### What is Vesugen?

Vesugen is a synthetic Lys-Glu-Asp tripeptide studied as a vascular-axis bioregulator in the Khavinson short-peptide series.

### What tissue is it associated with?

The blood-vessel wall and endothelium — each bioregulator in the series is framed around a specific target tissue.

### How strong is the evidence?

It is concentrated in a single research tradition and is largely preclinical, so findings are preliminary. This page is a research and educational reference.

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Source: AmericanPeptide.com — https://www.americanpeptide.com/catalog/vesugen
Data license: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Attribution: AmericanPeptide.com.
Research reference only — computational and educational content, not medical advice.