Reproductive

Kisspeptin-10

C-terminal decapeptide fragment of kisspeptin; potent GnRH secretagogue.

Overview

Kisspeptin-10 (KP-10) is the minimum bioactive fragment of kisspeptin, encoded by KISS1. Administration stimulates hypothalamic GnRH release and downstream LH / FSH secretion.

Mechanism

KISS1R (GPR54) agonism on hypothalamic GnRH neurons.

Research areas

Reproductive endocrinology
Hypothalamic amenorrhea
Puberty

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