MitochondrialLongevityMetabolic

MOTS-c

Mitochondrially-encoded peptide with reported insulin-sensitizing activity.

Overview

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA region. Preclinical studies report improved insulin sensitivity, AMPK activation, and exercise capacity.

Mechanism

AMPK activation; modulation of folate / methionine cycle.

Research areas

Metabolic disease
Exercise physiology
Aging biology

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