Growth Hormone

Sermorelin

Also known as GRF 1-29 · Geref

Truncated GHRH(1-29) — historically the first GHRH analog approved by the FDA.

Overview

Sermorelin is the first 29 amino acids of endogenous GHRH and was approved by the FDA in 1990 (subsequently discontinued commercially) for diagnostic and pediatric GH deficiency use.

Mechanism

GHRH receptor agonism.

Research areas

GH axis evaluation
Pediatric GH deficiency (historical)

Related peptides

CJC-1295 (no DAC)

Modified GHRH(1-29) analog with short plasma half-life.

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CJC-1295 (with DAC)

Long-acting GHRH analog with a Drug Affinity Complex for albumin binding.

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Ipamorelin

Selective ghrelin receptor agonist (GHRP) with minimal cortisol / prolactin release.

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