Adverse Event

Also called AE · SAE · serious adverse event · side effect

An adverse event (AE) is any undesirable experience in a trial participant, whether or not related to the study drug. AEs are graded by severity (Grade 1–5) and causality. Serious adverse events (SAEs) include death, hospitalization, or permanent harm. Gastrointestinal AEs (nausea, vomiting, diarrhea) are the most commonly reported for GLP-1 agonists.