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Glossary/α-MSH
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Mechanisms & Biology

α-MSH

Also called alpha-melanocyte-stimulating hormone · alpha-MSH · melanocyte stimulating hormone

α-MSH (alpha-melanocyte-stimulating hormone) is a 13-amino-acid peptide cleaved from POMC (pro-opiomelanocortin). It is the primary endogenous agonist of melanocortin receptors, activating MC1R (pigmentation), MC3R (energy balance), MC4R (sexual response, appetite), and MC5R (exocrine secretion). Synthetic analogs of α-MSH include melanotan-2 and PT-141, and fragments include KPV.

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Research use only. This definition is an educational reference, not medical advice or dosing guidance.