C-Terminal Amidation

Also called C-terminal amide · amide terminus · -NH2

C-terminal amidation converts the free carboxyl group at the C-terminus to an amide (-NH₂). Many endogenous neuropeptides are naturally amidated; the modification mimics this biology, improves resistance to carboxypeptidase degradation, and can affect receptor binding. It is a frequent modification in research peptide synthesis.