Also called ghrelin receptor · growth hormone secretagogue receptor
GHS-R1a is the G protein-coupled receptor activated by ghrelin and synthetic GHRPs (ipamorelin, hexarelin, MK-677). It is distinct from the GHRH receptor; GHS-R1a signals through Gq/IP₃/Ca²⁺, whereas GHRH-R signals through Gs/cAMP/PKA. Co-activating both pathways produces synergistic GH release.
Research use only. This definition is an educational reference, not medical advice or dosing guidance.